Our previous article discussed the First of 3 strategies to support our blood sugar metabolism – the Short Chain Fatty acids.  To read the entire article click here. Today we will be discussing the second pathway – the Insulin Signaling Pathway.

  1. The SCFA Pathway
  2. Insulin Signaling Pathway
  3. AMPK Pathway

 

Insulin Signaling Pathway                       

The Insulin Signaling Pathway is   a biochemical pathway in which insulin improves the transfer of glucose into the cells. When we eat carbohydrates and sugar, the pancreas senses the rise in glucose and releases insulin to help with the transfer of glucose from the bloodstream.

Image from Apex Energetics

Alpha Lipoic Acid (ALA), chromium, biotin, vanadium, certain mushrooms, berberine and gymnema8 have all shown to affect the insulin receptor function – the “lock” which responds to insulin -“the key”. It works by helping the insulin receptor “lock”  respond better to the insulin “key” and  in turn assists in the entry of glucose into the cells.

Chromium, Vanidium, zinc,9 Alpha Lipoic Acid and magnesium9 to assist in a process that gets the glucose from “storage” in the body to the cell membrane so that the glucose can actually enter the cell. Once it is inside the cell, glucose is then used to either make energy called ATP or get stored as glycogen or fat for later use.

If insulin receptor locks are poorly functioning10, the insulin cannot attach properly or the receptor becomes resistant to insulin. All the communication and signaling process becomes weakened or disrupted.

Without a strong signaling, less glucose enters the cell for energy production.11 Blood glucose continues to rise which results in high blood sugar. Over time, this can create many health problems.

Excess glucose is absorbed by the liver cells12 and stored as glycogen. Once the liver is too full it starts converting the glucose into fatty acids for long term storage as fat. This process requires a lot of energy and can create fatigue after eating. This extra fat can eventually lead to fatty liver, which creates more problems with our metabolism and promote insulin resistance by the liver.

When an individual lives in a world of chronic high blood sugar, inflammation increases and can affect the kidneys, eyes, heart and brain. Thiamine, N-Acetyl Cysteine, Alpha Lipoic Acid, Vitamin E and other antioxidants help with this type of inflammation and related oxidative stress.

Key Products we carry at Renovare that support blood sugar balance and Insulin resistance issues: