From our previous 2 articles discussed the two strategies to support healthy blood sugar – the Short Chain Fatty acids and Insulin Signaling Pathway, we can see how we can improve. What we use to think was from our genetics – we now know is mostly from our lifestyle and we can change this.
Today we will be discussing the most exciting new pathway – the AMPK Pathway.
The SCFA Pathway
Insulin Signaling Pathway
AMPK is an signaling enzyme that acts as our “fat switch”. It determines whether we burn calories to make energy or store them as fat. If we are not making energy we are making fat and damaging free radicals.
Our lifestyle choices such as exercise and fasting activate this AMPK switch. Another powerful boost to this fat burning switch are supplements such as resveratrol, Alpha Lipoic Acid, burdock root, rose hips,short chain fatty acids, and berberine, can activate this AMPK switch.
What are the other benefits of activating our AMPK switch:
Reduces Sugar Cravings
Boosts fat burning and muscle building – key to successful weight loss
Below are a few of tissues and organs are impacted by this AMPK pathway.
It is really important to use professional grade supplements that actually work. It has been our experience that there are many inferior grade products on the market or products that have been stored in a warehouse for an undetermined amount of time. At Renovare, we carry only Pharmaceutical grade supplements.
Key Products we carry at Renovare that support the AMPK pathway:
Our previous article discussed the First of 3 strategies to support our blood sugar metabolism – the Short Chain Fatty acids. To read the entire article click here. Today we will be discussing the second pathway – the Insulin Signaling Pathway.
The SCFA Pathway
Insulin Signaling Pathway
Insulin Signaling Pathway
The Insulin Signaling Pathway is a biochemical pathway in which insulin improves the transfer of glucose into the cells. When we eat carbohydrates and sugar, the pancreas senses the rise in glucose and releases insulin to help with the transfer of glucose from the bloodstream.
Image from Apex Energetics
Alpha Lipoic Acid (ALA), chromium, biotin, vanadium, certain mushrooms, berberine and gymnema8 have all shown to affect the insulin receptor function – the “lock” which responds to insulin -“the key”. It works by helping the insulin receptor “lock” respond better to the insulin “key” and in turn assists in the entry of glucose into the cells.
Chromium, Vanidium, zinc,9 Alpha Lipoic Acid and magnesium9 to assist in a process that gets the glucose from “storage” in the body to the cell membrane so that the glucose can actually enter the cell. Once it is inside the cell, glucose is then used to either make energy called ATP or get stored as glycogen or fat for later use.
If insulin receptor locks are poorly functioning10, the insulin cannot attach properly or the receptor becomes resistant to insulin. All the communication and signaling process becomes weakened or disrupted.
Without a strong signaling, less glucose enters the cell for energy production.11 Blood glucose continues to rise which results in high blood sugar. Over time, this can create many health problems.
Excess glucose is absorbed by the liver cells12 and stored as glycogen. Once the liver is too full it starts converting the glucose into fatty acids for long term storage as fat. This process requires a lot of energy and can create fatigue after eating. This extra fat can eventually lead to fatty liver, which creates more problems with our metabolism and promote insulin resistance by the liver.
When an individual lives in a world of chronic high blood sugar, inflammation increases and can affect the kidneys, eyes, heart and brain. Thiamine, N-Acetyl Cysteine, Alpha Lipoic Acid, Vitamin E and other antioxidants help with this type of inflammation and related oxidative stress.
Key Products we carry at Renovare that support blood sugar balance and Insulin resistance issues:
Dementia is an epidemic in Arizona and America. Whether Alzheimer’s type dementia, vascular dementia, Parkinson’s Disease Dementia, Lewy Body dementia, mixed dementia or others, the result is the same. Loss of memory, declining mental function, loss of quality of life, and death. Neurodegenerative disease (most of which is Alzheimer’s or mixed type dementia) is the fastest growing cause of death in America. Dementia is the only major disease for which we have no effective drug treatment options.
Pfizer, a major American pharmaceutical giant, recently stated that they will be pulling out of Alzheimer’s treatment research. It has been 15 years since a new drug for Alzheimer’s was launched, reflecting one of the longest and most expensive losing streaks for Big Pharma. Now some in the industry are starting to question how long that commitment can last, after Pfizer announced it was pulling out of neuroscience research. Its decision means the race to find the first medicine to slow or halt Alzheimer’s type dementia must now proceed without one of the biggest forces in drug development.
John LaMattina, a former head of research and development at Pfizer, interprets the decision as a portent of things to come, and predicts other large drug makers will eventually follow suit.
What if the Solution was Not a Drug?
The FINGER study in Finland (https://www.ncbi.nlm.nih.gov/pubmed/25771249) showed remarkable improvements in the high-risk older group studied through Lifestyle Change. Dr. Dale Bredesen, neuroscience researcher and former professor of medicine at UCLA wrote the ground-breaking book, “The End of Alzheimer’s” documenting the 30 years of research in his lab and others showing that Alzheimer’s type dementia is really many diseases. The research shows at least 36 documented root causes of the neurodegenerative disease process. We don’t “get” Alzheimer’s type dementia like we get the flu. We develop it over many years – usually decades – as a result of our lifestyle failing to fit our unique genetic and epigenetic needs.
It’s not just genetic. That’s right. Our genes do NOT determine our health. They influence our health. It is the interaction of our lifestyle choices, our environment, and our genes known as epigenetics that determines which genes turn on and which stay turned off. For the majority of human diseases, our lifestyle choices far outweigh our genes in determining our health and wellness. This is Great News!
Discover Magazine did an excellent summary article in December 2018 issue entitled: “Alzheimer’s Under Attack – Armed with big data, researchers turn to customized lifestyle changes to fight the disease”. Dr. Leroy Hood, biomedical pioneer & chief science officer for one of our nation’s largest non-profit health care systems, says, “Alzheimer’s is a really complex disease that has been utterly intractable.” He goes on to say, “Taking a systems approach reflects my own conviction that these complex diseases almost never respond to a single drug.”
It takes a systems approach process to solve the multiple pieces of the puzzle behind each person with dementia. More importantly, we need to solve the unique puzzle of each sufferer of brain decline since we are each different. This is not a “one size fits all” approach since, in my experience, there is no one size that fits all. Often medical research studies look for what single factor (usually a drug) creates a benefit in a large study group creating statistical significance for the study group – not individuals. This model fails to address the fact that each of us is unique with a dozen or more “root causes” behind our brain degeneration and dementia. This current double-blind placebo-controlled research model is ill-suited to complex, chronic neurodegenerative diseases like dementia. These complex diseases have multiple lifestyle-related causes different for each individual and multiple interventions are needed for synergistic therapeutic benefits. Medical studies typically study just one drug or intervention at a time which is just not enough to shift the direction of an unusually difficult, complex disease process like dementia.
Dr, Timothy C. Gerhart, D.C., DABCI, Dip. Ac., BCN is the author of 4 books on lifestyle approaches to brain and body Wellness and practices in Peoria, Arizona. His most recent book, “Living Free of Dementia – Solving the Puzzle to Prevent and Reverse Cognitive Decline” is scheduled for release in March 2019.
His other books are: “7 Secrets to Wellness, Change Your Brain, Transform Your Life, & Why Am I Not Right Since My Concussion”. Dr. Gerhart understands that the word “doctor” means “teacher” and is available to present to groups to teach the approaches he uses to prevent and reverse cognitive decline.
It is evident in our culture, that the topic of whether to vaccinate our children or not can be a very volatile subject.
Vaccines were designed to evoke an immunity response to protect individuals from potential serious illnesses. This decision can however come at a high price. The risk of side effects may outweigh the benefits – ranging from mild to severe and even life altering.
Here is a short list of the potential vaccine risk involved. noted from the website of Dr. Jack Wolfson
Immediate side vaccine injury may include:
Change in behavior such as screaming, not eating or drinking
Lack of attention, focus, or visual contact
Physical regression- bed wetting, incontinence
Skin changes including local or systemic (eczema)
Long term vaccine injury results may include:
Loss of muscle control
Mental health issues
Sudden death – including Sudden Infant Death Syndrome (“Crib Death”)
At Renovare, we are passionate about providing you with information so that you can make an informed decision.
Please take the time to watch the video below and know that your vaccination choices for you and your family are not out of lack of knowledge or misinformation.
More information and links will be provided in future blogs – including how you can make a difference in the rights of choice that our legislature is trying to take from us.
What does good balance have to do with preserving memory and brain function?
Our cerebellum, at the base of our brain, governs balance, as well as precision, coordination, and timing. The movements of daily life keep our cerebellum in a constant state of activity.
It’s this constant activity that keeps the rest of our brain on its toes. A healthy cerebellum (with an active lifestyle) feeds our brain a steady stream of information to keep it actively firing.
Bad Balance Leads to Bad Brain Function
This explains why symptoms of cerebellum degeneration, such as bad balance, often tie into loss of memory, poor ability to learn, and weakened brain endurance. Our brain isn’t getting enough “activation” from our cerebellum to keep it charged and running well. Declining balance is also strongly linked to dementia!
Brain Overwhelm from Bad Balance
When our outer cerebellum degenerates, it no longer filters sensory input leading to brain overload.
Symptoms may include restless leg syndrome, tinnitus, hypersensitivity to stress, depression, fatigue, anxiety, and others that you wouldn’t think could be related to balance.
Do You have Balance Problems?
Do you wobble if you stand on one foot with your eyes closed more than 15 seconds?
Can you walk in a straight heel-to-toe line with your eyes closed without stumbling?
Can you stand with your feet together and close your eyes without swaying?
This could be a sign of compromised brain health and needs to be measured since “What Gets Measured, Gets Improved” With a balance test baseline, we can design a Balance Rehab Program to guide your improvements.
Many who think their balance is fine, are surprised when testing reveals early balance problems that can be helped
There are almost 5000 published papers on force plate balance testing showing it is the gold standard with diagnostic value in conditions ranging from concussion & traumatic brain injury to Parkinson’s disease.
The system we use has a normative database of over 17,000 test results so your results can show if you have the balance of someone years younger or years older than you.
The system shows a Fall Risk Assessment: Low, Medium, and High
The system shows your improvements eg. From high to low fall risk, from the balance of an 80 year-old to the balance of a 45 year-old.
This testing is critical to understanding brain & central nervous system, somatosensory, vestibular, and oculomotor systems.
It is ideal to have a baseline test of your balance. Should you have a concussion or traumatic brain injury, we can quickly see the effects and have a target for recovery.
A groundbreaking paper published in the Journal of Vestibular Research, Does Vestibular Damage Cause Cognitive Dysfunction in Humans,demonstrates that the degree of damage to the vestibular system is directly correlated to changes in the hippocampus, which is a key component of memory and higher cognitive function.
A more recent paper published in the journal Stroke entitled Association of Postural Instability With Asymptomatic Cerebrovascular Damage and Cognitive Declinen discusses the irrefutable link between poor balance, cognitive decline, and small blood vessel disease in the brain. Subjects that had a reduced ability to stand on one leg were clearly shown to have lower cognitive functions of memory and spatial awareness. The lead author of this study urged that those with postural instability (impaired balance) should receive special attention as they may be at greater risk of cognitive decline.
With early detection of balance problems, you have the ability to improve. As with anything else in your body, the longer you wait to act, the less likely you will be able to fully recover much needed function and perform at your highest ability.
The better your ability to balance, the better your ability to think!
Schedule Your Balance Test Now! Call us at (623) 776-0206.
Neuroinflammation or the Brain on Fire is the Root mechanism for Alzheimers, Parkinsons and many of our brain diseases. When our brain is on fire, our brain begins to degenerate. We lose volume and our brain begins to shrink from the inside and outside.
When we tip one way we are making neural connections in the brain, when we tip the other we are removing neural connections in the brain. This moves us towards Alzheimers and other types of dementia.
The research shows us 36 factors that influence towards Alzheimers or towards brain health. They include:
vitamin D – critical for brain health
essential fatty acids
brain derived neurotropic factors
how well our mitochondria works to make energy
glutathione (an essential molecule for antioxidant balance)
improving blood flow to our brain
Reducing oxidative stress
neurotransmitter hormone balance
optimizing our cortisol and stress hormones
improving GABA which is calming to our brain
How do we help people with Neurodegeneration? We help them by dealing with root issues – not covering up symptoms. We work by solving the puzzle of why we are having our issues. We use a functional medicine, functional neurology approach