The Journal of the American Medical Association reported a recent study showing that Vitamin D at 400 IU, 4000 IU, and 10,000 IU showed increasing loss of bone density (but not bone strength) as the dosage increased.
They tested Vitamin D alone just like a drug is tested. A flawed idea for a number of reasons. First is that Vitamin D is NOT A DRUG! It does not work in isolation and should always be taken with Vitamin K2 which directs the increasing calcium levels from Vitamin D supplementation into our bones and teeth. Without Vitamin K2 taken with Vitamin D, our calcium is deposited into our soft tissues leading to blood vessel, heart valve, and joint calcification.
The next problem was using a CT scan (lots of radiation to boot) to evaluate bone density. Bone STRENGTH is what matters, not just bone density. Fosamax, Bonivia, and other drugs of the bi-phosphonate class have been shown to increase bone density while weakening the bone leading to catastrophic bone failure and fracture for some.
The last problem is focusing on large group studies trying to find what works for “average”. In 36 years of practice, I have yet to meet an “average” patient. We are each unique.
So what works?
First, “What gets measure, gets improved”
This means testing Vitamin D and blood calcium levels first. If dangerously low, low, or even sub-optimum, we tailor a Vitamin D with K2 supplement at levels we think makes sense. We use therapeutic levels of both with the clinically effective MK7 version of Vitamin K2 at therapeutic levels above 320 mcg per day. Then we retest in 4 – 8 weeks to make sure it is working. If the retest shows levels too low, we may need to add in Vitamin A to activate the Vitamin D receptor, increase dosage, or support liver, kidney, and gut conversion of Vitamin D to it’s active form. Sunlight and photobiomodulation support this conversion.
We also use a urine test to measure rate of bone loss. When bone loss is excessive we need to solve the puzzle as to why and of course retest to make sure it works. If not improving we may need to add supplements like hydroxyapatite, choline-stabilized orthosilicic acid, biotin and others to support bone health. We may need to reduce the hormones of stress and excessive inflammation that melts away bone.
In short, we need to SOLVE THE PUZZLE for each patient to support strong, healthy bones for a lifetime. Rarely can you solve the puzzle with one drug or supplement. We need to discover the root causes of the problem and adjust our lifestyle – including supplements – to fit our unique needs and measure to make sure it works. There is no AVERAGE at Renovare. Everyone is unique & special and deserves to be treated as such.
Nitric oxide is a critical signaling or messenger molecule. In fact, it is one of the components that will determine how long you are going to live. NO is linked to heart health and sexual health. Nitric oxide is critical to healthy blood flow to the brain, brain health, formation of new synapses in the brain, and protecting brain blood vessels from vascular damage.
It causes arteries and bronchioles to expand, allows brain cells to communicate with each other, and causes immune cells to kill bacteria and cancer cells. Nitric oxide production is important in protecting the heart, brain, liver, and other organs from low oxygen damage.
Nitric oxide expands the blood vessels, increases the blood flow, and decreases plaque formation and blood clotting.
However, when the body senses high toxic emotional stress, overwork, under-exercise, or smoking it releases less nitric oxide and then atherosclerosis begins to develop.
Penile erection also depends on the release of nitric oxide. Viagra and other drugs like it that reduce erectile dysfunction cause enzymatic reactions that increase Nitric Oxide.
Atherosclerosis and impotence are closely related. That’s why it’s important to know the signs of nitric oxide deficiency and correct them. Do NOT ignore Erectile Dysfunction – it is a sign of serious heart disease.
On the average, we lose 10 percent of our body’s ability to make nitric oxide for every decade of life. By the age of 40, studies show that we make 50% less Nitric oxide than we did as a teenager.
Being sedentary leads to less Nitric oxide production because your body is not stimulating its production; production is stimulated during exercise. Eating foods that are low in nitrates and nitrites also leads to decreased Nitric oxide production. Your body can only create Nitric oxide if it has the necessary precursors or building blocks. There are three isoforms of the NOS enzyme:
- Endothelial (eNOS): a signaling molecule that increases blood flow and artery health.
- Neuronal (nNOS): a signaling molecule that increases brain health
- Inducible (immune system) (iNOS): a signaling molecule which can be cytotoxic. Helpful during acute infection but extremely damaging to our blood vessels if it stays elevated. We use Nitric Balance to decrease this form and elevate eNOS and nNOS.
Another problem is the presence of fluoride. When fluoride is present, it converts nitric oxide into the toxic and destructive nitric acid. Nitric oxide will react with fluorine, chlorine and bromine to form nitrosyl halides, such as nitrosyl chloride which is harmful.
Accelerated aging, along with chemical and metabolic stresses damage eNOS. The resulting endothelial dysfunction creates a host of vascular disorders including diminished circulation of oxygen & nutrients, hypertension, and occlusive arterial disease.
Symptoms that may indicate low Nitric Oxide:
- Fatigue or low energy levels
- High Blood Pressure or decreased heart function esp. congestive heart failure
- Anxiety, irritability, or depression
- Insomnia & other sleep problems
- Loss of libido (sex drive) or Erectile Dysfunction (E.D.)
- Declining stamina
- Decreased workout potential or less energy at the gym
- Less stamina / endurance
- Declining Memory or Concentration
- Asthma or poor lung function
- Weakening bones – esp. osteopenia or osteoporosis
The depletion of nitric oxide also depletes endorphins and dopamine, which are the feel-good hormones in the limbic system. As a result, we become susceptible to Alzheimer’s, anxiety, depression, and dementia.
How do I get tested for Nitric oxide deficiency?
We use the simple and painless Nitric Oxide test in our office. This $10 test includes gathering saliva in your mouth, collecting the saliva (with your finger or a wooden tongue depressor), and placing it on the strip. It takes about 10 seconds for the results. The testing strip will indicate whether you are deficient, low, or normal.
Nitric Oxide testing is also useful for monitoring your levels over time. After 1 month of supplementation, it is important to be rested in order to ensure that your levels are back up to normal. Each person will require different amounts of dietary nitrates, supplements, and exercise. You should be sure to monitor your levels, especially if symptoms return or any of the signs mentioned above begin to occur (high blood pressure, poor heart function, erectile dysfunction, etc).
How do I increase my Nitric Oxide levels if my test shows they are low?
- Low Level Laser Therapy (LLLT) improves nitric oxide, blood flow, and energy in the brain is emerging as one of the most effective tools for cognitive enhancement.
- Take a Nitric oxide supplement such as Nitric Balance
- Exercise (Cardio or Fat Burning Exercise) & lose weight
- Increase dietary nitrates and nitrites
- Beets and dark green leafy vegetables, celery, kale, spinach, bok choy, leeks
- Avoid stomach acid reducers
- Decrease use of mouthwash which kills healthy mouth bacteria that make NO
Berberine has a long history of medicinal use in Chinese and Ayurvedic medicine. It is a yellow colored phytonutrient compound found in several different plants, including goldenseal, Oregon grape and the barberry tree. PubMed alone has published over 2,800 studies on berberine. It’s properties have demonstrated anti-viral, anti-inflammatory, and immune enhancing. This incredible compound is also effective on fungus and bacteria and can even help with food poison.
A Summary of Berberine Benefits:
- Activates the master switch pathway called AMPK
- Lowers blood sugar
- Lowers inflammation
- Improves HDL
- Lowers lipid profile including serum cholesterol, LDL, and triglycerides
- Improves liver disease – nonalcoholic fatty liver disease
- Prevents oxidative damage
- Supports weight Loss
- Kills Cancer Cells
- Calms digestive disorders such as IBS and diarrhea
- Slows aging
- Protects against alzheimers
- Relieves depression and anxiety
Key Products we carry at Renovare that contain Berberine