PubMed, the NIH federal library of medical research, shows over 67,000 results for published research papers on Vitamin C.  Over 80 years of laboratory and clinical studies on high-dose ascorbate (Vitamin C) therapy show Vitamin C at moderate doses are preventative for infection and at very large doses are therapeutic.  The safety and effectiveness of Vitamin C make it a prime candidate for treatment of flu, cold, Covid, and other respiratory illnesses.

“The medical literature has ignored over 80 years of laboratory and clinical studies on high-dose ascorbate therapy,” Saul notes, adding that while it’s widely accepted that vitamin C is beneficial in fighting illness, controversy exists over to what extent. “Moderate quantities provide effective prevention,” he says, while “large quantities are therapeutic.”

  • Oral vitamin C at doses of 2 to 8 grams a day have been shown to reduce the incidence and duration of respiratory infections
  • Intravenous vitamin C at 6 to 24 grams a day has been shown to reduce mortality, ICU admission rates, hospital stays and time on mechanical ventilation in patients with severe respiratory infections
  • An international vitamin C campaign has been launched in response to the landmark review

As reported in the paper “Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect Against Viral Infections,” published April 23, 2020:1

“The role nutrition plays in supporting the immune system is well-established. A wealth of mechanistic and clinical data show that vitamins, including vitamins A, B6, B12, C, D, E, and folate; trace elements, including zinc, iron, selenium, magnesium, and copper; and the omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid play important and complementary roles in supporting the immune system.

Inadequate intake and status of these nutrients are widespread, leading to a decrease in resistance to infections and as a consequence an increase in disease burden.”  1 Nutrients April 23, 2020; 12(4): 1181

Clinical Evidence

The Nutrients review17 also includes clinical evidence for the role of vitamin C in COVID-19, noting that early oral supplementation might help prevent a mild case from developing into something more serious. In patients with critical symptoms, intravenous administration of vitamin C has been shown to speed up recovery, reducing both ICU stays and mortality.

Interestingly, vitamin C deficiency and COVID-19 share many of the same risk factors, including male gender, darker skin, older age and comorbidities such as diabetes, high blood pressure and COPD. All of these subgroups are at increased risk for severe COVID-19 and, according to the authors, all “have also been shown to have lower serum vitamin C levels.”

Commenting on the clinical evidence supporting the use of vitamin C in the treatment of COVID-19, the authors write:18

“There are currently 45 trials registered on Clinicaltrials.gov investigating vitamin C with or without other treatments for COVID-19. In the first RCT to test the value of vitamin C in critically ill COVID-19 patients, 54 ventilated patients in Wuhan, China, were treated with a placebo (sterile water) or intravenous vitamin C at a dose of 24 g/day for 7 days …

The more severely ill patients with SOFA [sequential organ failure assessment] scores ≥ 3 in the vitamin C group exhibited a reduction in 28-day mortality: 18% versus 50% in univariate survival analysis (Figure 2). No study-related adverse events were reported.”

How Much Vitamin C Do You Need?

While high-dose vitamin C regimens typically call for intravenous administration, if treating a viral infection at home (be it COVID-19 or something else), you could use oral liposomal vitamin C, as this allows you to take far higher doses without causing loose stools.

You can take up to 100 grams of liposomal vitamin C without problems and get really high blood levels, equivalent to or higher than intravenous vitamin C. I view that as an acute treatment, however. I discourage people from taking mega doses of vitamin C on a regular basis if they’re not actually sick, because it is essentially a drug — or at least it works like one.

Saul, who has worked with and recommended vitamin C for most of his professional life suggests taking “enough vitamin C to be symptom-free,” whatever dosage that might be.

Everyone is different so ask your experienced care provider to help you find the dosage and form of Vitamin C that best fits your unique needs.

To learn more: https://articles.mercola.com/sites/articles/archive/2021/01/07/high-dose-vitamin-c-for-coronavirus.aspx